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Minocycline Activity against Unusual Clinically Significant Gram-Negative Pathogens
Dee Shortridge1, S J Ryan Arends1, Jennifer M Streit1
1JMI Laboratoriesgrid.419652.d, North Liberty, Iowa, USA.
Antimicrobial Agents and Chemotherapy
|September 7, 2021
Summary
Minocycline demonstrates high susceptibility rates against unusual Gram-negative pathogens like Burkholderia and Stenotrophomonas maltophilia. These findings support minocycline as a viable treatment option for infections caused by these bacteria.
Area of Science:
- Antimicrobial resistance
- Clinical microbiology
- Infectious diseases
Background:
- Gram-negative bacterial infections pose significant treatment challenges.
- Emerging and non-fermenting Gram-negative bacteria often exhibit resistance to common antibiotics.
- Minocycline is a tetracycline-class antibiotic with broad-spectrum activity.
Purpose of the Study:
- To evaluate the in vitro minocycline susceptibility of various Gram-negative bacterial species.
- To assess the utility of minocycline for treating infections caused by less common Gram-negative pathogens.
Main Methods:
- Analysis of 3,856 bacterial isolates collected between 2014 and 2019 as part of the SENTRY surveillance program.
- Determination of minocycline susceptibility percentages (%S) for specific species including Burkholderia, Achromobacter, Alcaligenes, Aeromonas, Chryseobacterium, and Stenotrophomonas maltophilia.
Main Results:
- High minocycline susceptibility was observed across multiple species: Achromobacter spp. (92.6%), Burkholderia cepacia complex (85.9%), Aeromonas spp. (99.2%), Chryseobacterium spp. (94.9%), Alcaligenes faecalis (88.1%), and S. maltophilia (99.5%).
- Stenotrophomonas maltophilia and Aeromonas spp. showed near-universal susceptibility to minocycline.
Conclusions:
- Minocycline exhibits favorable in vitro activity against a range of unusual Gram-negative pathogens.
- The data suggest minocycline is a potentially valuable therapeutic option for infections caused by these bacteria.
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