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Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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Striatal DAT availability does not change after supraphysiological glucose loading dose in humans.

Kyoungjune Pak1, Seongho Seo2, Myung Jun Lee3

  • 1Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Endocrine Connections
|September 7, 2021
PubMed
Summary
This summary is machine-generated.

Physiological glucose loading alters striatal dopamine transporter (DAT) availability in humans. High-dose glucose did not significantly change DAT availability, suggesting sub-regional insulin-mediated regulation.

Keywords:
dopamine plasma membrane transport proteinsglucoseinsulinobesity

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Area of Science:

  • Neuroscience
  • Radiochemistry
  • Endocrinology

Background:

  • Dopamine transporter (DAT) regulates brain dopamine levels by clearing extracellular dopamine.
  • Glucose metabolism influences neuronal function and neurotransmitter systems.

Purpose of the Study:

  • To investigate the effect of varying glucose loading doses on striatal dopamine transporter (DAT) availability in healthy human subjects.
  • To explore potential sub-regional differences in DAT regulation by glucose and insulin.

Main Methods:

  • Positron Emission Tomography (PET) imaging using the radiotracer 18F-FP-CIT was performed in 23 healthy males.
  • Subjects received intravenous glucose loading at low (300 mg/kg) or high (600 mg/kg) doses, or placebo (normal saline).
  • Striatal binding potential (BPND) was measured in the ventral striatum (VST), caudate nucleus, and putamen over 90 minutes.

Main Results:

  • Low-dose glucose significantly increased BPND in the VST, caudate nucleus, and putamen.
  • High-dose glucose also increased BPND, but to a lesser extent than low-dose glucose.
  • Significant differences in BPND were observed between placebo, low-dose, and high-dose glucose conditions in the caudate nucleus and putamen.

Conclusions:

  • Striatal DAT availability is modulated by physiological, but not supraphysiological, glucose loading in humans.
  • Correlations between BPND in the caudate nucleus and putamen suggest shared regulatory mechanisms.
  • Sub-regional variability in DAT regulation by insulin may exist within the human striatum.