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Evidence of digoxin metabolism by the kidney
G Koren1, J Klein, M Silverman
1Department of Pediatrics, Hospital for Sick Children, Toronto, Ont., Canada.
Canadian Journal of Physiology and Pharmacology
|December 1, 1987
Abstract:
By performing single pass experiments in the dog, we could identify by thin layer chromatography a digoxin metabolite produced by the kidney. In vitro studies verify that this new species is produced by the brush border membrane of the renal tubular cell.