Bisabolane-type sesquiterpenoids: Structural diversity and biological activity

Area of Science:

• Natural Product Chemistry
• Pharmacology
• Medicinal Chemistry

Background:

• Bisabolane-type sesquiterpenoids are monocyclic compounds found widely in nature.
• They exhibit a broad spectrum of biological activities.
• These compounds have been utilized in traditional medicines for centuries.

Purpose of the Study:

• To review the phytochemical and biological properties of natural bisabolane-type sesquiterpenoids.
• To provide a reference for future research and drug development.
• To consolidate information on 356 compounds isolated between 1985 and 2020.

Main Methods:

• Literature review of phytochemical and biological studies.
• Analysis of compounds from 24 plant and animal families.
• Compilation of data on reported pharmacological effects.

Main Results:

• Antibacterial, anti-inflammatory, and cytotoxic effects are the most frequently reported properties.
• A total of 356 bisabolane-type sesquiterpenoids were identified and reviewed.
• Compounds were isolated from diverse sources including Compositae, Zingiberaceae, and marine organisms.

Conclusions:

• Bisabolane-type sesquiterpenoids represent a rich source of pharmacologically active natural products.
• Their diverse biological activities underscore their potential for novel drug discovery.
• Further research into these compounds could lead to the development of new therapeutic agents.