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The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish
Abdulrahman Aziz Rasoul1, Zhikal Omar Khudhur2, Majeed Salih Hamad3
1Kurdistan Board of Medical Specialties (KBMS), Kurdistan Region, Iraq.
Background:
Multiple sclerosis (MS), as a neurodegenerative disorder, exhibits inflammation and oxidative stress hallmarks.
Objective:
The research aims to know any disturbances in haematological parameters and antioxidant system of relapsing-remitting multiple sclerosis (RRMS) patients in the Kurdish population.
Methods:
A case-control research meeting following the McDonald criterion was conducted on 100 RRMS patients and 100 controls.
Results:
Lipid peroxidation products of malondialdehyde (MDA), erythrocyte sedimentation rate (ESR), and total leucocyte counts (TLCs) were increased significantly, but copper (Cu+2) and superoxide dismutase (SOD) were decreased significantly while nitric oxide metabolites (NOx) and lymphocyte were not changed significantly if compared with that of controls.
Conclusion:
Findings from our study revealed that some defects were detected in haematological profiles in the Kurdish population and disturbance of immunological parameters. In addition, the utilization of Cu+2 supplement as an effective modality for RRMS patients may be beneficial.
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