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Imbalances in Cardiac Output01:26

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Mitral Stenosis I: Introduction01:22

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Updated: Oct 21, 2025

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in G&#246;ttingen Minipigs and Landrace Pigs
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Decrease of left ventricular ejection fraction in severe illness patients due to COVID-19 may improve as the disease

Aykut Demirkıran1, Lütfi Çağatay Onar2, Mustafa Doğan3

  • 1Department of Cardiology, Tekirdağ Dr. İsmail Fehmi Cumalıoğlu City Hospital, Tekirdağ, Turkey.

Turkish Journal of Medical Sciences
|September 8, 2021
PubMed
Summary
This summary is machine-generated.

COVID-19 patients without elevated troponin showed no permanent heart failure. Severe illness can cause temporary decreases in left ventricular ejection fraction (LVEF), which improve after recovery.

Keywords:
COVID-19left ventricular ejection fractionmyocardial dysfunction

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Cardiovascular Imaging

Background:

  • COVID-19 has raised concerns about long-term cardiac complications.
  • Myocardial involvement in COVID-19 necessitates understanding the burden of heart failure post-pandemic.
  • Focus on patients without elevated troponin levels to isolate specific cardiac effects.

Purpose of the Study:

  • To investigate the course of myocardial systolic function in COVID-19 patients without elevated troponin.
  • To assess the potential for permanent left ventricular systolic dysfunction after COVID-19 infection.

Main Methods:

  • Prospective study excluding patients with high troponin levels.
  • Two echocardiographic assessments: one during hospitalization and one at one-month follow-up.
  • Measurement of left ventricular ejection fraction (LVEF) using the biplane method of disks.

Main Results:

  • Significantly lower LVEF in severe COVID-19 cases compared to mild/moderate cases during hospitalization (50 ± 6% vs. 59 ± 6%).
  • Fifteen patients (43 ± 4%) in the severe group exhibited decreased LVEF (<50%) with global hypokinesia.
  • LVEF improved to normal levels within one month post-recovery in these patients (43 ± 4% to 55 ± 2%).

Conclusions:

  • No permanent systolic dysfunction was observed in COVID-19 patients without elevated troponin one month after recovery.
  • Transient myocardial dysfunction can occur in severe COVID-19 cases with normal troponin levels.
  • LVEF may decrease during the acute phase but typically improves during recovery.