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Association of coagulation disturbances with severity of COVID-19: a longitudinal study

Huimin Lu1, Ming Chen1, Shaoqiu Tang2

  • 1Department of Intensive Care Unit, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, People's Republic of China.

Hematology (Amsterdam, Netherlands)
|September 8, 2021
PubMed

Insights

Severe COVID-19 patients exhibit significant hypercoagulability, with elevated activated partial thromboplastin time (APTT), D-dimer, and fibrinogen. These coagulation changes in severe cases may link to early inflammation, unlike in non-severe cases.

Area of Science:

  • Medical research
  • Hematology
  • Infectious diseases

Background:

  • Coagulation dysfunction is a key factor in COVID-19 patient care, even with normal inflammation.
  • Understanding coagulation changes is crucial for managing COVID-19.

Purpose of the Study:

  • To analyze coagulation function indices in COVID-19 patients.
  • To compare coagulation characteristics between non-severe and severe COVID-19 cases.
  • To investigate potential mechanisms of coagulation dysfunction in COVID-19.

Main Methods:

  • Included 143 COVID-19 patients.
  • Collected clinical characteristics, coagulation function, and inflammatory factor data.
  • Compared indices based on disease severity (non-severe vs. severe).

Main Results:

  • Severe COVID-19 patients showed significantly higher APTT, D-dimer, and fibrinogen levels.
  • In severe cases, all three indices exceeded normal ranges and correlated with early inflammation.
  • Non-severe patients showed increasing trends, with only fibrinogen above normal, and no correlation with inflammation.

Conclusions:

  • Severe COVID-19 patients display more evident hypercoagulability.
  • Coagulation changes in severe COVID-19 may relate to early inflammatory factor increases.
  • Other factors likely contribute to abnormal coagulation in non-severe COVID-19 patients.
Abstract

Keywords:
COVID-19D-dimeractivated partial thromboplastin timecoagulationcytokinesdisseminated intravascular coagulationfibrinogenprocalcitonin

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