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The relationship between cannabis use and IVF outcome-a cohort study
Eden Har-Gil1, Ayala Heled2, Marjorie Dixon3,4
1Health Sciences - Wilfrid Laurier University, Waterloo, ON, Canada.
Journal of Cannabis Research
|September 8, 2021
Summary
Cannabis use in IVF patients showed no significant negative impact on pregnancy rates or embryo quality. This study suggests potential reassurance for individuals undergoing fertility treatments while using cannabis.
Area of Science:
- Reproductive Science
- In Vitro Fertilization (IVF)
Background:
- Cannabis use and its reproductive effects have been studied for decades, with evolving findings.
- Recent legalization of recreational cannabis in Canada necessitates updated research on its impact on fertility treatments.
Purpose of the Study:
- To investigate the association between cannabis use and in vitro fertilization (IVF) outcomes.
- To compare IVF success rates and key reproductive parameters between cannabis users and non-users.
Main Methods:
- Retrospective cohort study conducted at a single IVF center.
- Analysis included non-donor, male-female IVF patients categorized as cannabis users or non-users.
- Key outcomes assessed were ongoing pregnancy rate, oocyte yield, fertilization, and embryo quality.
Main Results:
- The study included 722 patients, with 9.4% identified as cannabis users (mostly light users).
- No significant differences were observed in implantation rates (40.74% vs. 41.13%) or ongoing pregnancy rates (35.2% vs. 29.1%) between users and non-users.
- No statistically significant differences were detected in oocyte yield, fertilization, estradiol levels, or embryo quality.
Conclusions:
- Findings suggest that cannabis consumption may not have demonstrable detrimental effects on IVF outcomes.
- Limitations include the retrospective design, self-reported cannabis use, and a small sample size of users.
- Further validation through larger, prospective studies is recommended.
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