Related Experiment Video
Updated: Oct 21, 2025

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Time-series analyses of directional sequence changes in SARS-CoV-2 genomes and an efficient search method for
Kennosuke Wada1, Yoshiko Wada1, Toshimichi Ikemura1
1Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Tamura-cho 1266, Nagahama-shi, Shiga-ken 526-0829, Japan.
Abstract:
We first conducted time-series analysis of mono- and dinucleotide composition for over 10,000 SARS-CoV-2 genomes, as well as over 1500 Zaire ebolavirus genomes, and found clear time-series changes in the compositions on a monthly basis, which should reflect viral adaptations for efficient growth in human cells. We next developed a sequence alignment free method that extensively searches for advantageous mutations and rank them in an increase level for their intrapopulation frequency. Time-series analysis of occurrences of oligonucleotides of diverse lengths for SARS-CoV-2 genomes revealed seven distinctive mutations that rapidly expanded their intrapopulation frequency and are thought to be candidates of advantageous mutations for the efficient growth in human cells.
Related Concept Videos
Viral Mutations
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Single Nucleotide Polymorphisms-SNPs
Evolutionary Relationships through Genome Comparisons

