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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Related Experiment Video

Updated: Oct 21, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Measuring success in IVF is a complex multidisciplinary task: time for a consensus?

Laura Rienzi¹, Danilo Cimadomo¹, Alberto Vaiarelli¹

¹Clinica Valle Giulia, GeneraLife IVF, Rome, Italy.

Reproductive Biomedicine Online

|September 8, 2021

Summary

This summary is machine-generated.

Defining successful in vitro fertilization (IVF) requires considering live birth rates alongside patient risks, costs, and satisfaction. A holistic approach ensures comprehensive success metrics beyond just the primary outcome.

Keywords:

Cost-effectiveness Cumulative live birth rate IVF success Patient-centeredness Time to pregnancy

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Published on: July 26, 2019

Area of Science:

Reproductive Medicine
In Vitro Fertilization (IVF) Outcomes
Healthcare Economics

Background:

The primary goal of IVF is live birth, but current metrics may not fully capture treatment success.
A comprehensive definition of IVF success is needed to align with patient and clinical realities.

Purpose of the Study:

To review and highlight the multifaceted aspects of defining success in IVF.
To advocate for a broader definition of IVF success incorporating clinical, financial, and patient-centered factors.

Main Methods:

Commentary and review of existing literature and clinical practices in IVF.
Analysis of primary outcomes (live birth rate) and secondary considerations (risks, costs, patient satisfaction).

Main Results:

Success in IVF should integrate cumulative live birth rates with risk-benefit analyses, financial costs, and patient-reported satisfaction.
Minimizing treatment discontinuation after failed attempts is crucial for patient well-being and data integrity.

Conclusions:

A consensus is needed to establish a standardized, holistic definition of IVF success.
Continuous monitoring and adjustment of IVF data, considering patient characteristics and national/international registers, are essential.