Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.3K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.8K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.0K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibroblastic aspartoacylase suppresses TGFβ-mediated responses and cancer progression.

Nature communications·2026
Same author

Fibroblast Activation Protein Alpha (FAP) Expression Is Associated with Disease Recurrence and Poor Response to Tyrosine Kinase Inhibitors in Advanced Clear Cell Renal Cell Carcinoma.

International journal of molecular sciences·2025
Same author

Transcriptional network analysis of PTEN-protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication.

Molecular oncology·2025
Same author

Duration of Menopause, Rather than Primary Hyperparathyroidism Severity, Predicts Osteoporosis in Postmenopausal Women: A Pilot Study from a Spanish Reference Center.

Journal of clinical medicine·2025
Same author

Migratory responses in enucleated cells: The forces driving the locomotion movement of unicellular organisms.

PNAS nexus·2025
Same author

Corrigendum to "The main sources of molecular organization in the cell. Atlas of self-organized and self-regulated dynamic biostructures" [Prog. Biophys. Mol. Biol. 195 (2025) 167-191].

Progress in biophysics and molecular biology·2025

Related Experiment Video

Updated: Oct 21, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

1.1K

Precision sampling fuels precision oncology: an evolutionary perspective.

Claudia Manini1, Estíbaliz López-Fernández2, José I López3

  • 1Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy.

Trends in Cancer
|September 8, 2021
PubMed
Summary

Intratumor heterogeneity (ITH) in tumors requires updated sampling methods for precision oncology. A cost-effective strategy for ITH detection and characterization was modeled in clear cell renal cell carcinoma.

Keywords:
ecologyintratumor heterogeneityprecision oncologyprecision samplingtherapytumor evolution

More Related Videos

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.0K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

875

Related Experiment Videos

Last Updated: Oct 21, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

1.1K
Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.0K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

875

Area of Science:

  • Oncology
  • Pathology
  • Genomics

Background:

  • Malignant tumors exhibit significant intratumor heterogeneity (ITH).
  • ITH poses challenges for effective cancer treatment and management.
  • Precision oncology relies on accurate characterization of tumor variability.

Purpose of the Study:

  • To emphasize the need for updated sampling protocols to address ITH.
  • To propose a strategy for detecting and characterizing ITH.
  • To model a cost-effective sampling strategy for clear cell renal cell carcinoma (CCRCC).

Main Methods:

  • Review of current sampling protocols in oncology.
  • Development of a conceptual framework for ITH detection.
  • Cost-effectiveness modeling applied to clear cell renal cell carcinoma (CCRCC) sampling.

Main Results:

  • Current sampling protocols may not adequately capture tumor variability.
  • A strategic approach is necessary for reliable ITH detection.
  • A cost-effective sampling strategy has been successfully modeled for CCRCC.

Conclusions:

  • Updating sampling protocols is crucial for advancing precision oncology.
  • Implementing ITH detection strategies is essential for personalized cancer care.
  • The modeled strategy offers a viable approach for CCRCC research and clinical practice.