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A preliminary metabolic study of alpidem in rat and man
P Padovani1, P Guinebault, S Vajta
1Laboratoire d'Etudes et de Recherches Synthélabo Paris, France.
European Journal of Drug Metabolism and Pharmacokinetics
|October 1, 1987
Abstract:
The metabolism of alpidem, a new anxiolytic agent in the chemical series of imidazopyridines, was investigated in rat and man. In both species the compound is extensively metabolised by three main routes of biotransformation: aromatic oxidation of the imidazopyridine ring; n-dealkylation; and/or aliphatic oxidation of the substituted amide side chains.