Related Experiment Videos
Synthesis, biological activity and conformational analysis of some acyclic cholinergic ligands
M De Amici1, C De Micheli, P Pratesi
1Istituto Chimico, Farmaceutico, Università di Milano, Italy.
Il Farmaco; Edizione Scientifica
|December 1, 1987
Abstract:
A selected number of acyclic analogs of muscarine were synthesized and tested on rat jejunum. A conformational analysis carried out on compounds (I) and (II), with the Allinger's MM2 program, evidenced that their very low muscarinic activity can be related to the low percentage of the "active conformation" present in solution.