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Related Experiment Videos

Electron beam therapy for eyelid carcinomas.

C Sinesi1, M D McNeese, L J Peters

  • 1Department of Clinical Radiotherapy, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston, TX 77030.

Head & Neck Surgery
|September 1, 1987
PubMed
Summary
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Electron beam radiotherapy effectively treated eyelid basal cell and squamous cell carcinomas, with a 10.9% recurrence rate. Most recurrences were managed surgically, preserving the eye and achieving good cosmetic outcomes.

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Dermatology

Background:

  • Eyelid carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are common skin malignancies.
  • Radiotherapy, particularly electron beam irradiation, has been utilized for eyelid tumor treatment.

Purpose of the Study:

  • To evaluate the efficacy and outcomes of electron beam radiotherapy for eyelid carcinomas.
  • To assess treatment-related sequelae and cosmetic results following radiotherapy.

Main Methods:

  • Retrospective analysis of 54 patients with eyelid BCC and SCC treated with electron beam radiotherapy between 1963 and 1983.
  • Variable radiation doses (45-72 Gy) and daily fractions (2.12-4.0 Gy) were administered.
  • Lesion characteristics, pretreatment surgical history, and post-treatment outcomes were recorded.

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Main Results:

  • A total of 54 eyelid carcinomas (46 BCC, 8 SCC) were treated, with lesion sizes up to 4 cm.
  • Six recurrences (10.9%) occurred, with three in-field and three at the margin.
  • Four recurrences were controlled with surgery preserving the eye; two required enucleation.
  • Good to excellent cosmetic results were achieved in 44 patients; significant deformity was associated with tumor destruction or prior surgery.

Conclusions:

  • Electron beam radiotherapy is an effective treatment for eyelid carcinomas, offering good local control and favorable cosmetic outcomes.
  • Careful patient selection and management of recurrences are crucial for optimal results.
  • While radiotherapy can cause sequelae, significant complications were infrequent in this cohort.