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Related Experiment Video

Updated: Oct 21, 2025

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Tunnelling a calcified total occlusion.

Jogendra Singh1, Dibyasundar Mahanta1, Rudra P Mahapatra2

  • 1Department of Cardiology, 410775All India Institute of Medical Sciences, India.

Asian Cardiovascular & Thoracic Annals
|September 8, 2021
PubMed
Summary
This summary is machine-generated.

Treating calcified coronary artery total occlusions is challenging. Intravascular lithotripsy offers an evolving alternative approach for plaque modification in complex coronary interventions.

Keywords:
Coronary arteryangioplastycalcificationchronic total occlusionintravascular lithotripsythoracic aorta

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Area of Science:

  • Interventional Cardiology
  • Vascular Biology
  • Biomedical Engineering

Background:

  • Calcified total occlusions in coronary arteries present significant challenges for interventional cardiologists.
  • Complex cases require advanced techniques to ensure successful revascularization.
  • Rotational atherectomy is a traditional method, but alternatives are being explored.

Purpose of the Study:

  • To describe a novel approach for treating calcified total coronary artery occlusion.
  • To evaluate the use of intravascular lithotripsy as an alternative to rotational atherectomy.

Main Methods:

  • A 48-year-old male patient with calcified total occlusion of the right coronary artery was treated.
  • The chronic total occlusion was successfully crossed using a Nic-Nano balloon.
  • Calcific plaque modification was performed using intravascular lithotripsy.

Main Results:

  • The Nic-Nano balloon facilitated crossing the chronic total occlusion.
  • Intravascular lithotripsy effectively modified the calcific plaque.
  • This approach represents a potential alternative for complex calcified lesions.

Conclusions:

  • Intravascular lithotripsy is a viable and evolving alternative technique for modifying calcific plaque in coronary artery total occlusions.
  • This case highlights a promising strategy for complex coronary interventions.