The investigation of the cerebral venous system in multiple sclerosis

Bateman et al. (2021) shows that multiple sclerosis (MS) is strongly associated with raised pressure in the superior sagittal sinus (SSS) and increased jugular bulb height above the sigmoid sinus. These findings are consistent with an increased aqueductal CSF pulse, as previously described in MS. They reinforce the hypothesis that intracranial compliance is reduced in MS and that internal jugular vein abnormalities contribute to SSS hypertension. However, the contribution of this to the pathophysiology of MS has not been established. Further investigation is therefore needed to determine what role, if any, these changes play in the complex puzzle of MS.