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Transcranial Direct Current Stimulation Modulates Connectivity of Left Dorsolateral Prefrontal Cortex with

Kamin Kim1, Matthew S Sherwood2, Lindsey K McIntire3

  • 1University of California, Davis.

Journal of Cognitive Neuroscience
|September 8, 2021
PubMed
Summary
This summary is machine-generated.

Transcranial direct current stimulation (tDCS) alters brain network connectivity. Anodal tDCS to the left dorsolateral prefrontal cortex (lDLPFC) enhanced functional connectivity within the frontoparietal control network (FPCN) for Brodmann

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Brain Stimulation

Background:

  • Transcranial direct current stimulation (tDCS) is known to modulate neuronal excitability and functional network connectivity.
  • The precise impact of tDCS on the connectivity patterns between targeted regions and the broader brain network structure remains incompletely understood.
  • The left dorsolateral prefrontal cortex (lDLPFC) is a common target for tDCS aimed at improving cognitive functions.

Purpose of the Study:

  • To investigate the effects of anodal tDCS on the functional connectivity of the lDLPFC within the human brain's network structure.
  • To quantify changes in lDLPFC connectivity using graph theory measures derived from resting-state fMRI data before and after stimulation.
  • To compare the effects of active tDCS versus sham stimulation on lDLPFC connectivity metrics.

Main Methods:

  • Anodal tDCS was applied to the lDLPFC, with the cathode placed on the right bicep.
  • Resting-state functional magnetic resonance imaging (fMRI) scans were acquired pre- and post-stimulation.
  • Graph theory measures were used to analyze changes in lDLPFC functional connectivity, comparing active and sham stimulation conditions.

Main Results:

  • Anodal tDCS to lDLPFC increased functional connectivity between Brodmann's area (BA) 9 and other nodes within the frontoparietal control network (FPCN).
  • For BA 46, while net connectivity strength within the FPCN remained unchanged, the participation coefficient (connectivity distribution across networks) decreased.
  • These distinct effects were observed following active tDCS compared to sham stimulation.

Conclusions:

  • tDCS induces specific alterations in the functional connectivity profile of the lDLPFC.
  • The observed changes suggest that tDCS may influence cognitive functions by modulating the lDLPFC's role and integration within brain networks, particularly the FPCN.
  • Increased involvement of the lDLPFC within the FPCN may underlie behavioral changes associated with tDCS.