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Monochromic light reduces emergence delirium in children undergoing adenotonsillectomy; a double-blind randomized
Adam C Adler1,2, Brian H Nathanson3, Arvind Chandrakantan4,5
1Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, 6621 Fannin Street, Houston, TX, USA. adam.adler@bcm.edu.
Insights
Monochromatic blue light significantly reduced emergence delirium in children after anesthesia. This non-pharmacologic approach offers a safer alternative to sedatives for managing post-operative confusion and agitation.
Area of Science:
- Anesthesiology
- Pediatric Medicine
- Ophthalmology
Background:
- Emergence delirium (ED) is a common, distressing post-anesthesia complication in children, characterized by confusion and agitation.
- Current treatments for ED involve sedatives, which can prolong recovery times.
- ED can lead to self-injury and parental distress.
Purpose of the Study:
- To investigate the efficacy of monochromatic blue light (MBL) in reducing the incidence of emergence delirium in pediatric patients.
- To assess the impact of MBL on Pediatric Anesthesia Emergence Delirium (PAED) scores.
Main Methods:
- A double-blind, randomized controlled study involving 104 pediatric patients (ages 2-6) undergoing adenotonsillectomy.
- Patients were randomized to receive either sham blue light or MBL for the initial 30 minutes of recovery.
- Primary outcome was the incidence of ED; secondary outcomes included PAED scores.
Main Results:
- The incidence of ED was significantly lower in the MBL group (5.9%) compared to the sham group (33.3%) (p=0.001).
- MBL exposure resulted in a reduced adjusted relative risk of ED (0.18; 95% CI [0.06, 0.54]; p=0.001).
- Fewer patients in the MBL group experienced ED or high PAED scores (23.5%) versus the sham group (52.9%) (p=0.002).
Conclusions:
- Monochromatic blue light is an effective non-pharmacologic intervention for reducing emergence delirium in children.
- MBL significantly decreases the incidence and severity of ED and associated PAED scores post-inhalational anesthesia.
- This finding supports MBL as a safe and viable alternative to pharmacological interventions for pediatric post-anesthesia care.
Background:
Emergence delirium (ED) is common in pediatric anesthesia. This dissociative state in which the patient is confused from their surroundings and flailing can be self-injurious and traumatic for parents. Treatment is by administration of sedatives which can prolong recovery. The aim of this study was to determine if exposure to monochromatic blue light (MBL) in the immediate phase of recovery could reduce the overall incidence of emergence delirium in children following general inhalational anesthesia.
Methods:
This double blinded randomized controlled study included patients ages 2-6 undergoing adenotonsillectomy. Postoperatively, 104 patients were randomization (52 in each group) for exposure to sham blue or MBL during the first phase (initial 30 min) of recovery. The primary outcome was the incidence of emergence delirium during the first phase. We also examined Pediatric Anesthesia Emergence Delirium (PAED) scores throughout the first phase.
Results:
Emergence Delirium was reported in 5.9% of MBL patients versus 33.3% in the sham group, p = 0.001. Using logistic regression adjusting for age, weight, gender, ASA classification and PAED scores provided an adjusted relative risk ratio of 0.18; 95% CI (0.06, 0.54); p = 0.001 for patients in the MBL group. 23.5% of MBL patients versus 52.9% of sham patients had either ED or PAED scores of 12 or more throughout the first phase of recovery, p = 0.002. This produced an adjusted relative risk of 0.46, 95% CI (0.29, 0.75), p = 0.001.
Conclusions:
Monochromatic blue light represents a non-pharmacologic method to reduce the incidence of emergence delirium and PAED scores in children.
Trial Registration:
#NCT03285243 registered on 15/09/2017.
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