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Characteristics associated with Lactobacillus iners-dominated vaginal microbiota.
Juliano Novak1, Jacques Ravel2, Bing Ma3
1Department of Pathology, São Paulo State University (Unesp), Medical School, Botucatu, São Paulo, Brazil juliano.novak@unesp.br.
Sexually Transmitted Infections
|September 9, 2021
Summary
Lactobacillus iners dominance in vaginal microbiota is linked to increased Candida colonization and fewer sexual partners. This suggests L. iners may not offer optimal protection, impacting women's health.
Area of Science:
- Microbiology
- Human Health
- Public Health
Background:
- The role of Lactobacillus iners in vaginal microbiota is debated.
- L. iners is a dominant species in many women globally.
- Understanding factors associated with L. iners dominance is crucial for reproductive health.
Purpose of the Study:
- To identify sociodemographic, behavioral, and clinical factors associated with L. iners-dominated community state type (CST) III.
- To assess the protective role of L. iners in the vaginal microbiota of Brazilian women.
Main Methods:
- Analysis of V3-V4 16S rRNA gene sequencing data from 442 Brazilian women.
- Comparison of L. iners-dominated CST III with CSTs dominated by other Lactobacillus species.
- Logistic regression analysis to identify associated variables.
Main Results:
- L. iners-dominated CST III was associated with having two or more sexual partners and Candida sp. detection.
- Condom use, higher education, and dairy intake were inversely associated with CST III.
- L. iners dominance was linked to increased risk of Candida colonization.
Conclusions:
- Sociodemographic and behavioral factors like unprotected sex and number of partners can identify women with L. iners-dominated microbiota.
- L. iners may not provide optimal protection against Candida colonization.
- Further research is needed to understand the implications of L. iners dominance.
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