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Updated: Oct 21, 2025

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
Published on: February 22, 2022
High-Intensity Interval Training and Cardiometabolic Risk Factors in Children: A Meta-analysis
Monserrat Solera-Martínez1,2, Ángel Herraiz-Adillo3, Ismael Manzanares-Domínguez1
1Health and Social Research Center.
Context:
High-intensity interval training (HIIT) has been widely used to prevent and treat cardiovascular risk factors in adolescents and adults; nevertheless, the available evidence in children is scarce.
Objective:
To synthesize evidence regarding the effectiveness of HIIT interventions on improving cardiovascular risk factors and cardiorespiratory fitness (CRF) in children from 5 to 12 years old.
Data Sources:
We searched 5 databases, Medline, Embase, SPORTDiscus, the Cochrane Library, and Web of Science.
Study Selection:
Randomized controlled trials (RCTs) evaluating the effectiveness of HIIT interventions on cardiometabolic risk factors and CRF in children were included.
Data Extraction:
Meta-analyses were conducted to determine the effect of HIIT on body composition, cardiometabolic and CRF variables in comparison with nontraining control groups.
Results:
A total of 11 RCTs and 512 participants were included. The results of the meta-analysis revealed a significant improvement in peak oxygen uptake (standardized mean difference [SMD] = 0.70, 95% confidence interval [CI] = 0.28 to 1.12; P = 0.001], in total cholesterol [SMD = -1.09, 95% CI = -1.88 to -0.30; P = 0.007], in low-density lipoprotein cholesterol [SMD = -1.28, 95% CI = -2.34 to -0.23; P = 0.017] and triglycerides [SMD = -0.71, 95% CI = -1.15 to -0.28; P = 0.001) levels.
Limitations:
Because of the small number of available RCTs, it was not possible to conduct a subgroup analysis or a linear meta-regression analysis.
Conclusions:
HIIT is a feasible and time-efficient approach for improving CRF, total cholesterol, low-density lipoprotein cholesterol, and triglycerides levels in children.
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