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Airway inflammation in severe asthmatics with acid gastro-oesophageal reflux

Nicole Tanner1, Sejal Saglani2,3, Albert M Li1

  • 1Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Thorax
|September 9, 2021
PubMed

Insights

Gastro-oesophageal reflux (GOR) is not linked to worse asthma control in children. This study found no significant differences in airway inflammation or remodelling in children with or without acid GOR, suggesting it

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology
  • Allergy and Immunology

Background:

  • The link between childhood asthma and gastro-oesophageal reflux (GOR) remains unclear.
  • Adult studies suggest GOR exacerbates asthma control and alters airway proteomics.
  • Investigating GOR's role in pediatric severe asthma is crucial for effective management.

Purpose of the Study:

  • To determine if acid GOR is associated with poorer asthma control in children.
  • To assess the impact of acid GOR on airway inflammation and remodelling in pediatric severe asthma.
  • To clarify the role of GOR as a comorbidity in severe childhood asthma.

Main Methods:

  • A cohort of 127 children with severe asthma was evaluated.
  • Participants underwent bronchoscopy and esophageal pH monitoring.
  • Asthma control, airway inflammation, and airway remodelling markers were assessed.

Main Results:

  • No significant differences in asthma control were observed between children with and without acid GOR.
  • Measures of airway inflammation and remodelling did not differ between the groups.
  • Acid GOR did not correlate with worse asthma outcomes in this pediatric cohort.

Conclusions:

  • Acid GOR does not appear to be a significant comorbidity impacting severe asthma control in children.
  • These findings suggest current management strategies for pediatric severe asthma may not need to prioritize GOR.
  • Further research could explore non-acidic reflux or other confounding factors in pediatric asthma.

Keywords:
histology/cytologypaediatric asthma

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