[The immune microenvironment of multiple myeloma]

The cancer immunoediting theory states that selective pressure by the immune system can sculpt tumor phenotypes and genotypes during all stages of tumor development. Multiple myeloma development has been recognized as a multistage process that includes premalignant expansion of plasma cells, symptomatic progression, and recurrent relapses. We discuss the dynamic crosstalk between the immune system and malignant plasma cells in light of the cancer immunoediting theory. Myeloma progression triggers dramatic alterations in the bone marrow, including bone destruction, inflammation, and angiogenesis, thereby generating an immunosuppressive milieu. We also present an overview of the immune microenvironment in multiple myeloma.