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Current approaches to fate mapping and lineage tracing using image data.

Steffen Wolf1, Yinan Wan2, Katie McDole1

  • 1MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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|September 9, 2021
PubMed
Summary

Researchers review methods for tracking cell lineages in developing embryos. Advances in imaging, labeling, and computational analysis allow unprecedented insights into cell fates and embryonic development.

Keywords:
Cell trackingDevelopmental biologyFate mappingLight-sheet imagingLineage tracingLive imaging

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Bioimaging

Background:

  • Cell lineage tracing is crucial for understanding embryonic development.
  • Historical efforts have been limited by technological constraints.
  • Recent advancements offer new possibilities for detailed investigation.

Purpose of the Study:

  • To review current strategies for cell lineage tracing using live-imaging data.
  • To outline computational and software methodologies for cell-tracking challenges.
  • To highlight the integration of lineage tracing with genomics and transcriptomics.

Main Methods:

  • Live-imaging microscopy techniques.
  • Advanced cell labeling strategies.
  • Computational analysis of complex image datasets.
  • Genomics and single-cell transcriptomics.

Main Results:

  • Detailed investigations into cell fates are now possible.
  • New insights into embryonic development are being generated.
  • Integration of multiple advanced technologies enhances understanding.

Conclusions:

  • Live-imaging and computational tools revolutionize cell lineage tracing.
  • Developmental biology benefits from integrated approaches.
  • Future research can further refine these powerful methodologies.