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Studies on mutagenicity of 3-chloropropylsulfide derivatives, potential antipsoriatic agents
H Strózyński1, M Strzelczyk, J Scianowski
1Department of Biology, Military Medical Academy, Lódź, Poland.
Polish Journal of Pharmacology and Pharmacy
|July 1, 1987
Abstract:
The mutagenicity of three sulfides--sulfur yperites--was investigated in vitro by a method of chromosome structural aberrations and sister chromatid exchange (SCE) on metaphasic chromosomes of the peripheral blood. The study demonstrated a relatively low mutagenicity of 2-chloroethyl-3-chloropropyl sulfide and permitted initiation of clinical investigation of this compound as a potential antipsoriatic agent.