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Extending human healthspan and longevity: a symposium report
Loren M DeVito1, Nir Barzilai2, Ana Maria Cuervo2
1Sticky Ink, Inc, New York, New York.
Annals of the New York Academy of Sciences
|September 9, 2021
Summary
The geroscience hypothesis suggests aging is malleable, not inevitable. Targeting aging mechanisms may prevent age-related diseases and extend healthspan, with clinical trials underway.
Area of Science:
- Gerontology
- Biomedical Research
- Aging Mechanisms
Background:
- Historically, aging and age-related diseases were considered irreversible.
- The geroscience hypothesis challenges this view, proposing aging is a targetable process.
Purpose of the Study:
- To explore the geroscience hypothesis and its implications for healthspan.
- To review advancements in targeting biological aging pathways.
- To discuss challenges and progress in clinical translation of geroscience therapies.
Main Methods:
- Review of current geroscience literature and research.
- Analysis of advancements in understanding aging mechanisms.
- Examination of novel and repurposed therapies targeting aging.
Main Results:
- Significant progress has been made in understanding aging mechanisms.
- Novel and repurposed therapies targeting aging pathways have been identified.
- Early-stage clinical trials are evaluating the feasibility of geroscience interventions.
Conclusions:
- Geroscience offers a paradigm shift, viewing aging as a malleable process.
- Targeting hallmarks of aging holds promise for preventing multiple age-related diseases.
- Clinical development faces hurdles, but ongoing trials aim to establish a regulatory pathway for future therapies.
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