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Gold nanoparticles in virus detection: Recent advances and potential considerations for SARS-CoV-2 testing
Jianxin Wang1,2, Adam J Drelich2, Caroline M Hopkins2
1Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|September 9, 2021
Summary
Gold nanoparticle (AuNP)-based diagnostics offer rapid and sensitive detection for viruses like SARS-CoV-2. This review highlights advances and future considerations for AuNP biosensing in pandemics.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Infectious Disease Diagnostics
Background:
- Viruses, including SARS-CoV-2, cause global health crises, necessitating rapid diagnostics.
- The COVID-19 pandemic underscores the critical need for effective and accessible virus detection methods.
- Gold nanoparticles (AuNPs) present a promising platform for advanced diagnostic tools.
Purpose of the Study:
- To review recent advancements in gold nanoparticle (AuNP)-based viral detection.
- To discuss design considerations for AuNP-based testing specific to SARS-CoV-2.
- To propose key parameters for developing future AuNP diagnostic platforms for pandemics.
Main Methods:
- Literature review of AuNP-based biosensing for viral detection.
- Analysis of design principles for AuNP assays targeting SARS-CoV-2.
- Identification of critical parameters for future AuNP diagnostic development.
Main Results:
- AuNP-based assays demonstrate significant potential for rapid and sensitive viral detection.
- Specific design strategies can enhance the efficacy of AuNP tests for SARS-CoV-2.
- Key parameters for future development include sensitivity, specificity, and scalability.
Conclusions:
- AuNP-based diagnostics are crucial for managing current and future viral outbreaks.
- Further research into AuNP assay design will improve pandemic preparedness.
- Effective AuNP biosensors are vital tools for global health security.
