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Updated: Oct 21, 2025

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
Published on: November 7, 2014
Determinants of gait speed in patients with heart failure with reduced ejection fraction
Aylin Tanrıverdi1, Buse Özcan Kahraman2, Serap Acar2
1Department of Institute of Health Sciences, Faculty of Medicine, Dokuz Eylül University; İzmir-Turkey.
Insights
Functional capacity and balance are key determinants of gait speed in heart failure with reduced ejection fraction (HFrEF). Improving these factors may enhance mobility and quality of life for HFrEF patients.
Area of Science:
- Cardiology
- Rehabilitation Medicine
- Gerontology
Background:
- Gait speed is a significant prognostic indicator in heart failure with reduced ejection fraction (HFrEF).
- Limited evidence exists on the functional factors influencing gait speed in HFrEF patients.
- Understanding these determinants is crucial for targeted interventions.
Purpose of the Study:
- To investigate the functional determinants of gait speed in patients diagnosed with HFrEF.
- To identify key factors that influence walking speed in this population.
Main Methods:
- A cross-sectional study involving 59 HFrEF patients.
- Gait speed measured via a 4-meter walk test.
- Functional capacity assessed using the 6-minute walk test (6MWT), and balance evaluated with the Berg Balance Scale (BBS).
- Dyspnea, functional mobility, and physical activity were also measured.
Main Results:
- Gait speed showed significant correlations with age, NYHA class, mMRC score, 6MWT, 5-STS test, BBS, and IPAQ scores.
- The 6-minute walk test (6MWT) distance and Berg Balance Scale (BBS) emerged as independent determinants of usual gait speed.
- These two factors explained 44.4% of the variance in gait speed.
Conclusions:
- Functional capacity and balance are independent predictors of gait speed in HFrEF patients.
- Interventions targeting functional capacity and balance may improve gait speed and outcomes in HFrEF.
Objective:
Given the prognostic significance of gait speed, there is insufficient evidence about possible functional determinants of gait speed in patients with heart failure with reduced ejection fraction (HFrEF). Therefore, the objective of this study was to investigate the functional determinants of gait speed in patients with HFrEF.
Methods:
Fifty-nine patients with HFrEF participated in this cross-sectional study. Demographic and clinical characteristics were recorded. The gait speed was determined with a 4-meter walking test. Dyspnea perception was assessed with the modified medical research council (mMRC) scale. Functional capacity was evaluated with a 6-minute walk test (6MWT). The five times sit-to-stand (5-STS) test and the Berg Balance Scale (BBS) were used to measure functional mobility and balance. Physical activity was evaluated with the International Physical Activity Questionnaire (IPAQ) Short-Form.
Results:
Gait speed was correlated with age (r=-0.368, p=0.004), NYHA functional class (r=-0.438, p=0.001), mMRC score (r=-0.422, p=0.001), 6MWT (r=0.650, p<0.001), 5STS (r=-0.506, p<0.001), BBS (r=0.586, p<0.001), IPAQ (r=0.305, p=0.019) and IPAQ-Sitting time (r=-0.327, p=0.011). On multiple linear regression analysis, the 6MWT distance and BBS were independent determinants of the usual gait speed in patients with HFrEF, accounting for 44.4% of the variance.
Conclusion:
This study indicates that functional capacity and balance are independent functional determinants of gait speed in patients with HFrEF.
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