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Updated: Oct 21, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Sodium sulphide promoted synthesis of fused quinoline at room temperature
Rashmi Singh1, Vishal Prasad Sharma1, Priyanka Yadav1
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India. ashishtewarichem@gmail.com.
Abstract:
A novel, simple and eco-friendly strategy for the synthesis of thiopyrano[4,3-b]quinolin-1-ones and pyrrolo[3,4-b]quinolin-1-ones from 2-alkynylquinoline-3-carbonitriles and sodium sulphide (Na2S·9H2O) under catalyst-free conditions at room temperature has been described. In this reaction, a readily available inorganic salt (Na2S·9H2O) serves as the sulphur source and leads to the generation of diverse functionalized thiopyrano[4,3-b]quinolin-1-ones and pyrrolo[3,4-b]quinolin-1-ones in moderate to excellent yields through sulfuration, annulation, and aerial oxidation.
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