Focal Cryoablation of Image-Localized Prostate Cancer

Focal cryoablation of localized prostate cancer can offer patients superior genitourinary functional outcomes in terms of preservation of urinary continence and potency compared with radical whole-gland therapy, while maintaining intermediate-term oncologic control. We present a step-by-step guide to focal cryoablation of localized prostate cancer. A patient with elevated prostate specific antigen (PSA) underwent multiparametric MRI (mpMRI) of the prostate that revealed a prostate imaging-reporting and data system (PI-RADS) four lesion. The patient subsequently had a transrectal ultrasound (TRUS)-guided MRI fusion biopsy of the target lesion as well as a systematic biopsy and was only found to have Gleason 3 + 4 prostate cancer in the 0.5 cc mpMRI target. The lesion plus a treatment margin was ablated with cryotherapy utilizing a traditional transperineal approach. Patient position, ultrasound and mpMRI image fusion, insertion of cryoablation needles, ablation of the prostate cancer lesion, and postoperative care were reviewed. Equipment used during the operation was itemized and described. This guide explores the necessary equipment, procedural steps, and tips for success when performing focal cryoablation of the prostate. The technique described represents the culmination of knowledge gathered with 30 years of experience performing cryoablation of prostate cancer. The accompanying video highlights the utilization of mpMRI and TRUS image fusion, triangulation of lethal ice around the prostate cancer lesion, and the importance of monitoring real-time ice formation with TRUS imaging. Cryoablation of prostate cancer can be applied to several clinical scenarios: partial-gland ablation, quadrant, hemiablation, focal-targeted, or whole gland in the primary or salvage settings. We present the surgical steps that are essential for effective focal ablation of image-localized prostate cancer.