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ConPlot: web-based application for the visualization of protein contact maps integrated with other data.

Filomeno Sánchez Rodríguez1,2, Shahram Mesdaghi1, Adam J Simpkin1

  • 1Institute of Structural, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.

Bioinformatics (Oxford, England)
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Summary
This summary is machine-generated.

ConPlot is a new web application for visualizing protein residue contact maps and distograms. This tool aids in interpreting predicted contact data by integrating other sequence-based predictions for enhanced structural feature inference.

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Area of Science:

  • Protein bioinformatics
  • Computational biology
  • Structural bioinformatics

Background:

  • Covariance-based predictions of residue contacts and inter-residue distances are vital in protein bioinformatics.
  • Integrating predicted contact data with other predictions is crucial for inferring protein structural features.

Purpose of the Study:

  • To present ConPlot, a novel web-based application for the display and analysis of protein contact maps and distograms.
  • To facilitate the interpretation of predicted contact maps by enabling the integration of diverse sequence-based predictions.

Main Methods:

  • ConPlot is a web application accessible at www.conplot.org.
  • It supports native reading of popular file formats and flexible display of bespoke data.
  • The application can also be installed locally using a Docker image.

Main Results:

  • ConPlot offers convenient display and analysis of contact maps and distograms.
  • It integrates other sequence-based predictions into the visualization using colored tracks.
  • The tool enhances the interpretation of predicted contact maps through novel visualization techniques.

Conclusions:

  • ConPlot provides a user-friendly platform for visualizing and analyzing protein contact predictions.
  • The integration of multiple data types in ConPlot aids in a more comprehensive understanding of protein structure.
  • This visualization tool is expected to streamline the interpretation of predicted protein contact data.