Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

9.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
9.8K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.9K
Truncation in Survival Analysis01:09

Truncation in Survival Analysis

347
Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
347
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

350
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
350
Censoring Survival Data01:09

Censoring Survival Data

284
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
284
Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

218
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
218

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective Memory for Virtual Cooking Tasks in Relation to Adaptive Functioning.

Assessment·2026
Same author

A Comparison of Virtual Reality and Traditional Measures of Memory in the Diagnostic Discriminability of Neurocognitive Disorders: A Virtual Kitchen Protocol Study.

Assessment·2026
Same author

Bone Pain Due to Granulocyte Colony-Stimulating Factors #523.

Journal of palliative medicine·2026
Same author

African American Communities Speak to Clinician 1. Program Creation and Implementation Feasibility.

Journal of pain and symptom management·2026
Same author

Variation in estimates of the footprint of large, ground-mounted photovoltaic solar energy in the United States and its associated land-cover change across three datasets.

Journal of environmental management·2025
Same author

Event Centrality, Not Posttraumatic Growth, Explains Trauma Symptom Course Among Sexual Assault Survivors.

Violence against women·2025
Same journal

Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

Chest·2026
Same journal

How I Do It: De-escalation of Prostacyclin-Based Therapy in Patients Treated With Sotatercept.

Chest·2026
Same journal

Eisenmenger Syndrome: The Pulmonology Perspective.

Chest·2026
Same journal

Phenotyping of pulmonary arterial hypertension associated with congenital heart disease using latent class analysis: insights from a national prospective registry.

Chest·2026
Same journal

Septic Shock and GLP-1 Analogue Association in Real World - A Propensity Score Matched Analysis.

Chest·2026
Same journal

PREVALENCE AND RISK FACTORS OF PRESERVED RATIO IMPAIRED SPIROMETRY (PRISm) IN PEOPLE WITH HIV AND MATCHED POPULATION CONTROLS.

Chest·2026
See all related articles

Related Experiment Video

Updated: Oct 21, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.8K

Communicating About Time-Limited Trials.

Kendall Downer1, Jillian Gustin2, Taylor Lincoln3

  • 1University of Alabama at Birmingham Medical Center, Birmingham, AL; UAB Center for Palliative & Supportive Care, University of Alabama at Birmingham Medical Center, Birmingham, AL.

Chest
|September 9, 2021
PubMed
Summary
This summary is machine-generated.

Time-limited trials (TLTs) improve critical care prognostication and family communication. The TIME mnemonic aids decision-making, enhancing patient-physician relationships and goal-concordant care.

Keywords:
communicationdecision-makingeducationend of lifeprognostication

More Related Videos

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.5K
The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents
10:27

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

7.1K

Related Experiment Videos

Last Updated: Oct 21, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.8K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.5K
The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents
10:27

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

7.1K

Area of Science:

  • Critical Care Medicine
  • Medical Ethics
  • Health Communication

Background:

  • Time-limited trials (TLTs) are crucial in critical care for managing patients with uncertain prognoses.
  • Poorly executed TLTs can lead to conflict, mistrust, and nonbeneficial interventions.
  • Effective communication is vital for shared decision-making in end-of-life care.

Purpose of the Study:

  • To introduce and evaluate the TIME mnemonic for improving communication around TLTs.
  • To enhance prognostication and foster consensus between families and intensivists.
  • To promote patient-centered care and reduce nonbeneficial treatments.

Main Methods:

  • The study proposes the TIME mnemonic: Truth about uncertainty, Interval of time, Measurement of improvement, End or extend.
  • This framework facilitates structured discussions regarding TLTs in critical care.
  • Application of the mnemonic aims to improve clarity and shared understanding.

Main Results:

  • The TIME mnemonic provides a structured approach to discussing prognosis and treatment goals.
  • It helps manage uncertainty and promotes flexibility in complex patient care.
  • Facilitates patient-centered decision-making and goal-concordant care.

Conclusions:

  • The TIME mnemonic enhances communication and decision-making in time-limited trials.
  • It supports improved patient-physician relationships and goal-concordant care.
  • This framework can potentially reduce nonbeneficial treatments at the end of life.