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Management experience of pediatric meningioma in a Mexican reference center
Alejandro Santana-González1, Monserrat Pérez-Ramírez1, Griselda Ramírez-Reyes2
1Servicio de Patología Pediátrica, Hospital de Pediatría "Dr. Silvestre Frenk Freud", Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico.
Objective:
Determine the histopathological and clinical characteristics of patients diagnosed with meningiomas and to establish the frequency of these tumors in the pediatric population Mexican. Determine the NF1/2 frequency in meningioma pediatric.
Methods:
Samples from the histopathology file were reviewed, and from the complete clinical file the following patient data was reviewed: age, gender, diagnosis, diagnosis year, surgical resection, location, tumor size, symptoms, and family background. The frequency of NF1/2 in pediatric meningioma was reviewed in literature.
Results:
Forty-four de novo cases were collected from pediatric patients; 19 were female patients and 25 males. The most frequent histological subtype was transitional meningioma. Of all the cases, 75% had a supratentorial localization and 20% had an extramedullary intrarachidian localization. Some clinical manifestations included seizures, paresis, headache, and visual disturbances.
Conclusion:
There is a low incidence of meningiomas in the pediatric population, more than 70% are Grade I, and they have supratentorial localization.
Insights
Pediatric meningiomas are rare, with most being benign (Grade I) and located in the supratentorial region. This study characterized their clinical and histopathological features in Mexican children.
Area of Science:
- Neuro-oncology
- Pediatric Pathology
- Clinical Neurology
Background:
- Meningiomas are uncommon in children, necessitating characterization of their specific features in this age group.
- Understanding the clinical and histopathological profiles of pediatric meningiomas is crucial for diagnosis and treatment.
- The frequency of neurofibromatosis type 1 (NF1) and type 2 (NF2) in pediatric meningioma requires further investigation.
Purpose of the Study:
- To determine the histopathological and clinical characteristics of pediatric meningiomas in Mexico.
- To establish the incidence of meningiomas within the pediatric population in Mexico.
- To assess the frequency of neurofibromatosis type 1 (NF1) and type 2 (NF2) in pediatric meningioma cases.
Main Methods:
- Retrospective review of histopathology and clinical files for pediatric meningioma cases.
- Data collected included patient demographics, tumor diagnosis, surgical details, location, size, symptoms, and family history.
- Literature review to determine the frequency of NF1/2 in pediatric meningioma.
Main Results:
- Forty-four pediatric meningioma cases were identified, with a slight male predominance (25 males, 19 females).
- Transitional meningioma was the most frequent histological subtype.
- Supratentorial localization occurred in 75% of cases, with 20% being extramedullary intraspinal.
- Common symptoms included seizures, paresis, headaches, and visual disturbances.
Conclusions:
- Meningiomas exhibit a low incidence in the pediatric population.
- The majority of pediatric meningiomas are World Health Organization (WHO) Grade I (over 70%).
- Supratentorial location is characteristic of pediatric meningiomas.