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Updated: Oct 21, 2025

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

Changes in placental elastography in the third trimester - Analysis using a linear mixed effect model.

Christopher Edwards¹, Erika Cavanagh¹, Sailesh Kumar²

¹School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, 4000, Australia; Mater Research Institute-University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, QLD, 4000, Australia; Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, QLD, 4000, Australia.

|September 9, 2021

Summary

This summary is machine-generated.

Ultrasound elastography measures placental shear wave velocity (SWV). Gestational age and amniotic fluid index (AFI) have minimal impact on SWV in the third trimester, aiding future pregnancy management.

Keywords:

In vivo Placenta Placental elasticity Shear-wave elastography Ultrasound longitudinal study

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Last Updated: Oct 21, 2025

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

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Published on: November 8, 2018

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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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Published on: August 2, 2017

Area of Science:

Obstetrics and Gynecology
Medical Imaging
Fetal Medicine

Background:

Ultrasound elastography is being researched for assessing placental health.
Uteroplacental dysfunction assessment using elastography requires understanding influencing factors.
Limited data exists on maternal and fetal factors affecting placental shear wave velocity (SWV).

Purpose of the Study:

To evaluate longitudinal changes in placental SWV throughout gestation.
To model SWV changes with maternal and fetal physiological characteristics.
To identify key predictors of placental SWV in singleton pregnancies.

Main Methods:

Longitudinal data collected from 238 singleton pregnancies (629 data points) in the 3rd trimester.
Linear mixed-effects model regression analysis employed.
Ten potential predictor variables were assessed for their impact on SWV.

Main Results:

Gestational age, amniotic fluid index (AFI), body mass index (BMI), and sample depth were significant predictors of placental SWV.
Gestational age and AFI demonstrated only a minimal impact on SWV.
Sophisticated statistical modeling indicated minimal influence from many expected third-trimester maternal and fetal changes.

Conclusions:

Placental SWV is minimally affected by gestational age and AFI in the third trimester.
Understanding factors influencing placental SWV is crucial for its clinical application in managing placental dysfunction.
Elastography shows potential for pregnancy management, but influencing factors require careful consideration.