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Syncope and COVID-19 disease - A systematic review
Raquel Falcão de Freitas1, Sofia Cardoso Torres2, Francisco Javier Martín-Sánchez3
1Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
Autonomic Neuroscience : Basic & Clinical
|September 9, 2021
Summary
Syncope, or fainting, can occur with COVID-19, often as an early symptom. Unexplained syncope is most common, and beta-blocker use may increase its incidence in COVID-19 patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Neurology
Background:
- Syncope is an uncommon but possible manifestation of COVID-19.
- It can present as an initial symptom, with various underlying mechanisms.
- Understanding the frequency and causes of syncope in COVID-19 is crucial.
Purpose of the Study:
- To investigate the frequency of syncope in patients with COVID-19.
- To identify the etiological factors contributing to syncope in this population.
- To analyze the association between syncope and specific medications.
Main Methods:
- A systematic review of relevant literature was conducted.
- Databases searched included PubMed, ISI Web of Knowledge, and SCOPUS.
- PRISMA guidelines were followed for study selection and data extraction.
Main Results:
- Syncope and pre-syncope occurred in 4.2% of 14,437 COVID-19 patients.
- Unexplained syncope was the predominant type (87.9%), followed by reflex syncope (7.8%).
- Beta-blocker use was associated with a higher incidence of syncope (p < 0.01).
Conclusions:
- Syncope can be associated with COVID-19, especially in early stages.
- Multiple etiologies contribute to syncope in COVID-19 patients.
- Reevaluation of blood pressure management and antihypertensive therapy, particularly beta-blockers, is recommended.
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