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Vitamin D Replacement Effect on Platelet Counts
Murat Bulent Kucukay1, Recep Alanli1
1Department of Internal Medicine, Faculty of Medicine, Lokman Hekim University, Ankara, Turkey.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|September 10, 2021
Summary
Vitamin D treatment significantly lowered platelet counts in patients with vitamin D deficiency. This finding suggests a potential therapeutic role for vitamin D in managing conditions characterized by elevated platelet levels.
Area of Science:
- Internal Medicine
- Endocrinology
- Hematology
Background:
- Vitamin D deficiency is prevalent and linked to various health conditions.
- Platelets play a crucial role in hemostasis and thrombosis.
- The impact of vitamin D on platelet parameters requires further investigation.
Purpose of the Study:
- To investigate the effect of vitamin D treatment on platelet counts.
- To analyze these effects across different age groups in patients with vitamin D deficiency.
Main Methods:
- An observational study conducted in outpatient clinics.
- 1,230 participants with vitamin D deficiency were enrolled and divided into three age groups.
- Complete blood count and vitamin D levels were compared before and after vitamin D replacement therapy.
Main Results:
- Vitamin D treatment led to a significant decrease in platelet counts and mean platelet volume.
- No significant changes were observed in hemoglobin or neutrophil counts.
- A significant correlation was found between vitamin D levels and changes in platelet counts post-treatment.
Conclusions:
- Vitamin D treatment effectively lowers platelet counts.
- This effect may offer therapeutic benefits for conditions like essential thrombocythemia.
- Further research is warranted to explore the clinical implications of vitamin D's impact on platelet levels.
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