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Recent Advances in Micro/Nanomaterial-Based Aptamer Selection Strategies
Dong-Min Kim1, Myeong-June Go2, Jingyu Lee2
1Center for Applied Life Science, Hanbat National University, Daejeon 34158, Korea.
Molecules (Basel, Switzerland)
|September 10, 2021
Summary
This review explores advanced aptamer discovery methods for detecting chemicals and biomolecules. It highlights micro/nanomaterial-based SELEX strategies, offering insights for developing superior aptamers.
Area of Science:
- Biotechnology
- Molecular Biology
- Analytical Chemistry
Background:
- Aptamers are nucleic acid ligands with diverse applications including diagnostics and therapeutics.
- Current aptamer discovery relies on systematic evolution of ligands by exponential enrichment (SELEX).
- Micro/nanomaterials offer novel platforms for enhancing SELEX efficiency and specificity.
Purpose of the Study:
- To review recent advances in aptamer discovery strategies.
- To focus on micro/nanomaterial-mediated SELEX platforms for chemical and biomolecule detection.
- To discuss the advantages, limitations, and future directions for high-performance aptamer development.
Main Methods:
- Classification of SELEX strategies into bead-mediated, carbon-based nanomaterial-mediated, and other nanoparticle-mediated approaches.
- Analysis of recent literature on micro/nanomaterial-enhanced aptamer discovery.
- Evaluation of the performance and applicability of different SELEX strategies.
Main Results:
- Recent SELEX strategies leverage micro/nanomaterials for improved aptamer selection.
- Bead-mediated, carbon-based, and other nanoparticle strategies show distinct advantages and limitations.
- These platforms facilitate the detection of various chemicals and biomolecules.
Conclusions:
- Micro/nanomaterial-mediated SELEX represents a significant advancement in aptamer discovery.
- Further research into these strategies can lead to the development of highly specific and sensitive aptamers.
- Optimized aptamers hold great promise for applications in diagnostics, therapeutics, and environmental monitoring.
