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Updated: Oct 21, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Chemo-Preventive Action of Resveratrol: Suppression of p53-A Molecular Targeting Approach

Rokeya Akter1,2, Md Habibur Rahman2,3, Deepak Kaushik4

  • 1Department of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, Bangladesh.

Molecules (Basel, Switzerland)
|September 10, 2021
PubMed

Insights

Resveratrol, a natural compound, shows significant promise in cancer prevention and treatment due to its anti-inflammatory and antioxidant properties. This review highlights its molecular mechanisms, particularly involving the p53 protein, and therapeutic potential.

Area of Science:

  • Natural Products Chemistry
  • Oncology
  • Molecular Biology

Background:

  • Natural products are crucial for preventing and treating various disorders, including cancer.
  • Resveratrol, a polyphenol from natural sources, exhibits significant therapeutic potential.
  • Its anti-inflammatory, antioxidant, cardioprotective, and anti-aging properties are well-documented.

Purpose of the Study:

  • To review the latest research on resveratrol's role in cancer prevention.
  • To explore resveratrol's impact on molecular signals, focusing on p53 protein.
  • To present the therapeutic prospects of resveratrol in cancer treatment.

Main Methods:

  • Literature review of experimental, clinical, and epidemiological studies.
  • Analysis of molecular mechanisms and signaling pathways.
  • Synthesis of recent findings on resveratrol's anticancer activity.

Main Results:

  • Resveratrol demonstrates potent anticancer effects through various mechanisms.
  • Its interaction with the p53 protein is a key factor in its therapeutic action.
  • Evidence supports resveratrol's role in cancer prevention and treatment.

Conclusions:

  • Resveratrol is a promising natural agent for cancer prevention and therapy.
  • Further research into its molecular targets, like p53, can optimize its clinical application.
  • An updated database on resveratrol's healing actions is essential for future studies.
Keywords:
cancer preventioncardio protectionclinical trialsmolecular signalsnatural compoundp53polyphenolred wineresveratrol

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