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Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years:

Su-Hyun Song1,2, Young-Jin Kim1,2, Hong-Sang Choi1,2

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, Korea.

Journal of Clinical Medicine
|September 10, 2021
PubMed

Insights

Persistent apparent treatment-resistant hypertension (ATRH) in chronic kidney disease (CKD) patients significantly increases the risk of adverse renal outcomes. Continuous monitoring and treatment are crucial for improving kidney health in these individuals.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Apparent treatment-resistant hypertension (ATRH) is common in chronic kidney disease (CKD) patients.
  • Long-term outcomes and the impact of ATRH improvement in CKD are not well understood.

Purpose of the Study:

  • To evaluate the relationship between the persistence of ATRH and the progression of CKD.
  • To determine the prognostic significance of sustained ATRH in CKD patients.

Main Methods:

  • A cohort study of 1921 CKD patients.
  • ATRH defined by specific blood pressure and medication criteria.
  • Patients categorized based on ATRH status at baseline and two-year follow-up.

Main Results:

  • Baseline ATRH prevalence was 14.0%.
  • Persistent ATRH (at both time points) was an independent risk factor for adverse renal outcomes (HR, 1.41; P=0.027).
  • ATRH at only one time point did not show statistical significance.

Conclusions:

  • Persistent ATRH, not transient status, is critical for renal disease prognosis.
  • Continuous patient follow-up and optimized treatment are essential for better renal outcomes in CKD.

Keywords:
apparent treatment-resistant hypertensionchronic kidney diseaseend stage renal diseaseprognosisrenal insufficiency

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