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[Desmoplastic melanoma].

J Piñól Aguadé, J Ferrando, J A Bombi

    Medicina Cutanea Ibero-Latino-Americana
    |January 1, 1977
    PubMed
    Summary
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    Desmoplastic melanoma, a rare skin cancer, presents superficially but recurs as subcutaneous tumors. Studies show it lacks melanocyte markers but exhibits lysosomal enzyme activity, suggesting a mesenchymal origin.

    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Desmoplastic melanoma is a rare variant of melanoma.
    • It is characterized by superficial lesions and subcutaneous relapses.
    • Histologically, it can resemble atypical fibroxantoma or fibrosarcoma.

    Observation:

    • Melanocyte-specific stains (silver, Dopa, tyrosinase, cholinesterase) were negative.
    • Tumor cells exhibited intense positivity for lysosomal enzymes (non-specific esterases, acid phosphatases).
    • Ultrastructural studies revealed tumoral cells with prominent nucleoli, dilated endoplasmic reticulum, lipid vacuoles, and abundant lysosomes, but no melanosomes.

    Findings:

    • Tumoral cells showed features distinct from typical melanocytes.
    • Abundant fibroblastic elements and increased collagen with abnormal periodicity were observed.

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  • The study supports a mesenchymal origin for desmoplastic melanoma.

    • Implications:

    • Desmoplastic melanoma requires careful histological and ultrastructural evaluation for accurate diagnosis.
    • Understanding its mesenchymal origin may guide future therapeutic strategies.
    • Further research into local and systemic factors influencing its development is warranted.