Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

6.0K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
6.0K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

6.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
6.6K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

6.2K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of a Novel VLDLR Variant in the First Report of CAMRQ1 From Africa: Expanding the Spectrum of Cerebellar Ataxia Syndromes.

Human mutation·2026
Same author

An Improved Deep Learning Algorithm for Breast Cancer Survival Prediction Based on Multi-Omics Data.

F1000Research·2026
Same author

Moderate-intensity statin plus ezetimibe as an alternative to high-intensity statin therapy.

Cardiovascular diabetology·2026
Same author

HMGCR genetic variation and risk of new-onset type 2 diabetes in statin users.

Human genomics·2026
Same author

AI-Assisted Impedance Biosensing of Yeast Cell Concentration.

Biosensors·2026
Same author

Combined Role of CYP3A4 and CYP3A5 genetic variants in tacrolimus dose-adjusted trough levels: a clinical retrospective study in kidney transplant patients.

The pharmacogenomics journal·2026

Related Experiment Video

Updated: Oct 20, 2025

Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry
12:34

Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry

Published on: December 6, 2017

11.8K

Electrical Detection of Innate Immune Cells.

Mahmoud Al Ahmad1, Rasha A Nasser2, Lillian J A Olule1

  • 1Department of Electrical Engineering, College of Engineering, UAE University, Al Ain 15551, United Arab Emirates.

Sensors (Basel, Switzerland)
|September 10, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces electrical characterization to distinguish between dendritic cells (DCs) and macrophages (MACs), key innate immune cells. This novel method offers a more specific and efficient way to classify immune cells for therapeutic research.

Keywords:
dendritic cellselectrical characterizationimage processingimmune systemmacrophages

More Related Videos

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

8.9K
Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung
09:57

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

7.1K

Related Experiment Videos

Last Updated: Oct 20, 2025

Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry
12:34

Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry

Published on: December 6, 2017

11.8K
Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

8.9K
Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung
09:57

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

7.1K

Area of Science:

  • Immunology
  • Cell Biology
  • Biophysics

Background:

  • Accurate classification of innate immune cells is crucial for understanding immune system interactions and developing therapies for inflammatory diseases and cancer.
  • Existing immunophenotyping techniques, such as flow cytometry, often suffer from limitations in specificity and require cross-referencing.
  • Advancements in cell characterization technologies are vital for progress in innate immunity research and therapeutic development.

Purpose of the Study:

  • To present a novel immunophenotyping technique utilizing electrical characterization to differentiate between dendritic cells (DCs) and macrophages (MACs).
  • To establish capacitance measurements as a reliable marker for cell size and surface area in distinguishing these innate immune cell types.
  • To validate the electrical characterization method against image processing for enhanced accuracy and specificity.

Main Methods:

  • In vitro differentiation of THP-1 cells into dendritic cells (DCs) and macrophages (MACs).
  • Electrical characterization using capacitance measurements to assess cell size.
  • Verification of capacitance readings using image processing techniques.

Main Results:

  • Distinct average capacitance readings were obtained for THP-1 cells (0.83 µF), DCs (0.93 µF), and MACs (1.01 µF).
  • The capacitance measurements directly correlated with cell size, with macrophages exhibiting the largest capacitance and size.
  • Image processing confirmed the results from electrical measurements, highlighting the technique's accuracy.

Conclusions:

  • Electrical characterization, specifically capacitance measurement, provides a novel, accurate, and specific method for differentiating between dendritic cells and macrophages.
  • This technique bypasses the limitations of marker specificity found in conventional methods like flow cytometry.
  • The ability to precisely classify innate immune cells using electrical properties opens avenues for improved predictive models and therapeutic strategies in immunology.