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Meningioma-Brain Crosstalk: A Scoping Review
Josefine de Stricker Borch1, Jeppe Haslund-Vinding1, Frederik Vilhardt2
1Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Cancers
|September 10, 2021
Summary
The tumor microenvironment in meningiomas is poorly understood. This review found limited evidence for tumor-brain crosstalk, suggesting it may only occur in invasive meningiomas affecting the brain parenchyma.
Area of Science:
- Neuro-oncology
- Tumor Microenvironment Research
- Cancer Pathogenesis
Background:
- The tumor microenvironment (TME) is crucial in cancer development.
- The TME of meningiomas and the role of glia cells remain largely uncharacterized.
- Understanding glia cell involvement is key to meningioma pathogenesis.
Purpose of the Study:
- To investigate literature on tumor-brain crosstalk in meningiomas.
- To summarize evidence on the brain parenchyma's role in meningioma pathogenesis.
- To explore the interaction between glia cells and meningioma.
Main Methods:
- Scoping review of studies identified via PubMed.
- Selection of articles focusing on glia cells and cytokines/chemokines in meningiomas.
- Review of existing literature on meningioma-brain interactions.
Main Results:
- Monocytes are the predominant immune cells in meningiomas.
- A monocytic response at the tumor-brain interface is observed only in brain-invasive meningiomas.
- Cytokine/chemokine expression and autocrine loops in tumor cells are partially studied, but paracrine interactions with glia cells are unexplored.
Conclusions:
- The extent of immune response elicited by meningiomas in the brain parenchyma is unknown.
- Tumor-brain crosstalk is hypothesized to be relevant primarily in invasive meningiomas that breach the pial-glial basement membrane.
