Related Experiment Video

Updated: Oct 20, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

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PIM Kinases in Multiple Myeloma

Jian Wu1, Emily Chu1, Yubin Kang1

  • 1Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Cancers
|September 10, 2021
PubMed

Insights

PIM kinases are crucial in multiple myeloma (MM). Inhibitors targeting these kinases show promise for treating MM, with ongoing research exploring combination therapies and immune system modulation for better outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Multiple myeloma (MM) is an incurable cancer requiring novel therapies.
  • PIM kinases (PIM1, PIM2, PIM3) regulate key cancer processes like growth, apoptosis, and drug resistance.
  • PIM kinases are implicated in myeloma tumorigenesis, making them therapeutic targets.

Purpose of the Study:

  • To review PIM kinase pathways and their role in MM.
  • To summarize the development status of PIM kinase inhibitors for MM treatment.
  • To highlight combinatorial strategies and future therapeutic potential.

Main Methods:

  • Literature review of PIM kinase pathways and inhibitors.
  • Analysis of current clinical trial data for PIM kinase inhibitors.
  • Exploration of PIM kinase interactions with other therapeutic agents.

Main Results:

  • Several PIM kinase inhibitors are in clinical trials for MM.
  • PIM kinase inhibition demonstrates potential for MM treatment.
  • Combination therapies with PIM inhibitors may enhance cytotoxic effects.

Conclusions:

  • PIM kinase inhibitors represent a promising therapeutic strategy for MM.
  • Further research is needed to elucidate PIM kinase roles in the immune microenvironment and synergy with immunomodulatory drugs.
  • Exploiting PIM kinases offers novel avenues for MM treatment.
Keywords:
PI3K/Akt/mTORPIM kinaseinhibitormultiple myelomaresistance

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