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Impact of Adjuvant Radiotherapy in Patients with Central Neurocytoma: A Multicentric International Analysis
Laith Samhouri1, Mohamed A M Meheissen2,3, Ahmad K H Ibrahimi4
1Department of Radiation Oncology, University Hospital Münster, Münster 48149, Germany.
Background:
Central neurocytoma (CN) is a rare tumor accounting for <0.5% of all intracranial tumors. Surgery ± radiotherapy is the mainstay treatment. This international multicentric study aims to evaluate the outcomes of CNs patients after multimodal therapies and identify predictive factors.
Patients And Methods:
We retrospectively identified 33 patients with CN treated between 2005 and 2019. Treatment characteristics and outcomes were assessed.
Results:
All patients with CN underwent surgical resection. Radiotherapy was delivered in 19 patients. The median radiation dose was 54 Gy (range, 50-60 Gy). The median follow-up time was 56 months. The 5-year OS and 5-year PFS were 90% and 76%, respectively. Patients who received radiotherapy had a significantly longer PFS than patients without RT (p = 0.004) and a trend towards longer OS. In addition, complete response after treatments was associated with longer PFS (p = 0.07).
Conclusions:
Using RT seems to be associated with longer survival rates with an acceptable toxicity profile.
