Related Experiment Video

Updated: Oct 20, 2025

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

9.4K

Hodgkin Lymphoma in People Living with HIV

Jose-Tomas Navarro1,2,3, José Moltó3,4, Gustavo Tapia3,5

  • 1Department of Hematology, Institute Català d'Oncologia-Germans Trias i Pujol Hospital, Carretera de Canyet s/n, 08916 Barcelona, Spain.

Cancers
|September 10, 2021
PubMed

Insights

Hodgkin lymphoma (HL) incidence has risen in people living with HIV (PLWH) despite combined antiretroviral therapy (cART). Effective cART during chemotherapy improves survival for PLWH with HL, necessitating collaborative care.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Virology

Background:

  • HIV-related lymphomas (HRL) remain a significant cause of morbidity and mortality in people living with HIV (PLWH).
  • While aggressive non-Hodgkin lymphoma incidence decreased with combined antiretroviral therapy (cART), Hodgkin lymphoma (HL) incidence has increased in PLWH.
  • Epstein-Barr virus coinfection is critical in the pathogenesis of HL within the HIV setting.

Purpose of the Study:

  • To review and update epidemiological, clinical, and biological aspects of HL in PLWH.
  • To emphasize advances in prognosis and contributing factors for HL in PLWH.
  • To highlight the importance of cART and interdisciplinary care in managing HL in PLWH.

Main Methods:

  • Literature review and synthesis of current data on HL in PLWH.
  • Analysis of epidemiological trends, clinical presentations, and biological mechanisms.
  • Evaluation of treatment strategies, including cART and chemotherapy, and their impact on prognosis.

Main Results:

  • The prognosis for HL in PLWH is improving and nearing that of the general population.
  • Effective cART during chemotherapy is associated with improved survival rates for all lymphoma subtypes, including HL.
  • Interdisciplinary collaboration is crucial for managing drug interactions and toxicities.

Conclusions:

  • HL in PLWH requires specialized, collaborative management integrating HIV and hemato-oncology expertise.
  • Advances in cART and chemotherapy have significantly improved outcomes for PLWH with HL.
  • Continued research into the pathogenesis and treatment of HL in PLWH is essential.

Keywords:
HIVantiretroviral therapyhodgkin lymphomaprognosis

More Related Videos

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

15.9K
Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment07:21

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

21.6K

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
479
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
421
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.3K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
47.7K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
11.4K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.6K