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Updated: Oct 20, 2025

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Review of Myeloma Therapies and Their Potential for Oral and Maxillofacial Side Effects
Sophie Beaumont1,2, Simon Harrison3,4,5, Jeremy Er5
1Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Abstract:
Myeloma is a common haematological malignancy in which adverse skeletal related events are frequently seen. Over recent years, treatment for myeloma has evolved leading to improved survival. Antiresorptive therapy is an important adjunct therapy to reduce the risk of bone fractures and to improve the quality of life for myeloma patients; however, this has the potential for unwanted side effects in the oral cavity and maxillofacial region. Osteonecrosis of the jaw related to antiresorptive medications and other myeloma therapies is not uncommon. This review serves to highlight the risk of osteonecrosis of the jaw for myeloma patients, with some suggestions for prevention and management.
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