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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Oct 20, 2025

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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Targeting Bone Metastasis in Cancers.

Edith Bonnelye1, Patricia Juárez2

  • 1Department of Efficacy and Resistance to Anti-Tumor Targeted Therapies, University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.

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This issue explores bone cancer (oncology) and how the bone microenvironment influences cancer spread and dormancy. Understanding these factors is key to developing new bone metastasis treatments.

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Area of Science:

  • Oncology and bone biology research.
  • Investigating the bone microenvironment in cancer progression.

Background:

  • Bone metastasis is a significant challenge in cancer care.
  • The interplay between the tumor and bone microenvironment is crucial for metastasis.

Discussion:

  • Focuses on the mechanisms of bone metastasis dormancy and progression.
  • Explores the role of the tumor microenvironment in bone metastasis.

Key Insights:

  • Highlights the complexity of bone physiopathology in oncology.
  • Emphasizes the need for integrated approaches to study bone metastasis.

Outlook:

  • Aims to advance understanding of bone metastasis for improved patient outcomes.
  • Encourages further research into targeted therapies for bone cancer.