Related Experiment Video
Updated: Oct 20, 2025
A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Might life-threatening acute pulmonary edema occur after using recombinant tissue plasminogen activator? A case
Xue-Bing Chen1, Dong Qu1,2, Qing Zhang3
1School of Forensic Medicine, Southern Medical University, 510515, Guangzhou, China.
Background:
Recombinant tissue plasminogen activator (rt-pa) is the first-line drug for the treatment of acute ischemic stroke, and can lead to some complications.There were rare reports of death due to acute pulmonary edema during rt-pa thrombolysis treatment.
Case Presentation:
This study reports a 30-year-old man was diagnosed with acute ischemic stroke and underwent rt-pa thrombolytic therapy. Finally he died despite active rescue.
Conclusions:
The autopsy revealed that he died of acute pulmonary edema. This case suggests that it is necessary to pay close attention to the changes of vital signs during thrombolysis and be aware of possibility of pulmonary edema during thrombolysis.
