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A BASIC program on heterokaryosis and survival in Phycomyces.

E S Salàn1, J L Diez, F M Fernàndez

  • 1Departamento de Gènetica, Facultad de Biologia, Universidad de Leòn,Spain.

Computer Applications in the Biosciences : CABIOS
|April 1, 1986
PubMed
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This study introduces a BASIC program to analyze spore survival and heterokaryosis in Phycomyces. The program computes lethal effects and mutation rates, aiding genetic studies.

Area of Science:

  • * Genetics
  • * Mycology
  • * Computational Biology

Background:

  • * Understanding genetic stability and mutation is crucial in fungal research.
  • * Phycomyces serves as a model organism for studying genetic phenomena.
  • * Previous computational tools for analyzing fungal genetics were limited.

Purpose of the Study:

  • * To develop a user-friendly BASIC program for analyzing survival and heterokaryosis in Phycomyces.
  • * To compute the impact of various lethal effects (mitotic, dominant, recessive) on spore populations.
  • * To determine mutation rates and their relationships under different lethal conditions.

Main Methods:

  • * Development of a BASIC program for APPLE II series microcomputers.
  • * Implementation of algorithms to calculate spore survival and heterokaryosis fractions.

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  • * Integration of calculations for uninucleate spore fractions and mutation probabilities.
  • * Design for adaptability to other BASIC-compatible microcomputers.

    • Main Results:

    • * The program successfully computes surviving and heterokaryotic spore fractions.
    • * It quantifies uninucleate spores resulting from mitotic and recessive lethals.
    • * The system calculates the probability of mitotic lethals per nucleus.
    • * It analyzes the interplay between mutation rates of concurrent mitotic and recessive lethals.

    Conclusions:

    • * The developed BASIC program provides a valuable tool for Phycomyces genetic analysis.
    • * It simplifies the computation of complex genetic parameters related to lethality and mutation.
    • * The program's adaptability ensures its utility across various microcomputing platforms.