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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Updated: Oct 20, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Melanoma Risk Factors and Prevention.

William W Dzwierzynski1

  • 1Department of Plastic Surgery, Medical College of Wisconsin, 1155 N. Mayfair Road, Milwaukee, WI 53226, USA.

Clinics in Plastic Surgery
|September 10, 2021
PubMed
Summary
This summary is machine-generated.

Melanoma, a rising cancer, develops from genetic and environmental factors, primarily ultraviolet radiation. Early detection and risk factor mitigation are key for prevention and surveillance.

Keywords:
MelanomaPreventionRisk factorsUV radiation

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Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Melanoma incidence is rapidly increasing, affecting 1 in 50 individuals in Western populations.
  • Melanoma development is multifactorial, involving genetic predisposition and environmental triggers.
  • Ultraviolet (UV) radiation is a significant cause, implicated in 60-70% of melanoma cases.

Purpose of the Study:

  • To summarize the etiology and risk factors of melanoma.
  • To highlight the importance of prevention strategies for melanoma.
  • To emphasize the need for increased surveillance in high-risk individuals.

Main Methods:

  • Literature review on melanoma incidence and risk factors.
  • Analysis of the multifactorial nature of melanoma development.
  • Evaluation of current prevention and surveillance strategies.

Main Results:

  • Melanoma incidence is rising faster than other malignancies.
  • UV radiation is a primary environmental cause of melanoma.
  • Genetic and environmental interactions drive melanoma development.

Conclusions:

  • Melanoma prevention requires addressing environmental risks like UV exposure.
  • Identifying individuals with phenotypic risk factors is crucial for enhanced surveillance.
  • A comprehensive approach combining risk mitigation and early detection is essential for combating melanoma.