Related Experiment Videos
A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis.
L Kirkup1, D J Nichols, J Sutherland
1Physics Department, Paisley College of Technology, Scotland.
Computer Applications in the Biosciences : CABIOS
|December 1, 1986
Summary
This study presents an affordable method to demonstrate mass transport and exchange using dye clearance in a hydrodynamic model. The technique is valuable for teaching fluid volume measurement and pharmacokinetic compartmental analysis.
Area of Science:
- Fluid dynamics
- Pharmacokinetics
- Biomedical engineering
Background:
- Mass transport and exchange are fundamental processes in various scientific disciplines.
- Demonstrating these concepts often requires complex or expensive equipment.
Purpose of the Study:
- To present a simple, inexpensive demonstration of mass transport and exchange.
- To illustrate the application of the indicator-dilution technique.
- To showcase compartmental analysis in pharmacokinetics.
Main Methods:
- Utilized a hydrodynamic model with dye clearance.
- Employed a microcomputer for data acquisition and storage.
- Applied non-linear least squares curve fitting for parameter estimation.
Main Results:
- Successfully demonstrated mass transport and exchange using the dye clearance method.
- Validated the use of microcomputer-based analysis for pharmacokinetic studies.
- The system proved effective for illustrating key concepts.
Conclusions:
- The described system offers a cost-effective and accessible method for demonstrating mass transport and exchange.
- It serves as a practical tool for teaching fluid volume measurement and pharmacokinetic compartmental analysis.